Production of Recombinant Proteins
Integrated Continuous Production of Recombinant Proteins
- Integrated Continuous Biomanufacturing
- Development of a supervisory control and data acquisition system for an integrated continuous biomanufacturing process based on modern process analyzers
Cell culture
- Ex vivo Expansion of Human Adipose Stromal Cells
- Development and design of continuous mammalian cell culture processes
- Optimization of mammalian cell perfusion cultures for the end-to-end continuous integrated production of therapeutic proteins
Chromatography
- Model-based design and optimization of multi-column chromatographic processes
- Determination of residence time distribution in twin-column processes
- Purification of proteins from human blood plasma with MCSG
- Fundamental Understanding of Peptide Adsorption in Reversed-Phase Chromatography
- Adsorption Equilibria of Proteins in Ion-Exchange Chromatography
Formulation
- Aggregation of therapeutic proteins from dilute to concentrated conditions
- Intermolecular interactions underlying the mechanisms and kinetics of protein aggregation