Dr. Thomas Müller-Späth

Resume

• 11/2008 - present
  PostDoc at the Institute for Chemical- and Bioengineering, Morbidelli-Group.
  Research Topics:
  - Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) of Proteins
  - Chromatographic Purification of Monoclonal Antibodies
  - Protein Analytics
• 01/2008 - present
  external page ChromaCon AG
  
• 10/2005 - 10/2008
  Doctorate studies at the Institute for Chemical and Bioengineering, Morbidelli-Group, Research topics:
  - Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) of Proteins
  - Chromatographic Purification of Monoclonal Antibodies
• 08/2005
  Graduation from the Technical University of Hamburg.
  Topic of Diploma Thesis:
  Modelling and Scale-Up of a High Cell Density Dialysis Fermentation of E.Coli in 30L scale
• 04/2004-11/2004
  Internship at Bayer Healthcare, Berkeley, CA, USA in Process and Technology Development.
  Topic of research: Physical Aspects of Scale Up of Packed-Bed Column Chromatography
• 09/2003-11/2003
  Internship at Beiersdorf AG, Hamburg, D in Product Development (Labello)
• 08/2002-05/2003
  Studies at University of California, Berkeley, CA, USA, Department of Chemical Engineering with DAAD scholarship for 1 academic year.
  Six-week research project. Topic: Fermentation of Extremophiles
• 10/1999
  Begin studies of Chemical Engineering at the Technical University of Hamburg, D
• 09/25/1979
  Born in Thessalonica, Greece

Publications

• Muller-Spath T, Aumann L, Morbidelli M. 2009. Role of Cleaning-in-Place in the purification of mAb supernatants using continuous cation exchange chromatography, Separation Science and Technology 44 (1): 1-26.
• Muller-Spath T, Aumann L, Melter L, Strohlein G, Morbidelli M. 2008. Chromatographic Separation of three Monoclonal Antibody variants using Multicolumn Countercurrent Solvent Gradient Purification (MCSGP), Biotechnology and Bioengineering 100 (6): 1166-1177.

Presentations

• Müller-Späth T, Aumann L, Ströhlein G, Kornmann H, Valax P, Delegrange L, Baer G, Lamproye A, Jöhnck M, Schulte M, Morbidelli M. 2008. Monoclonal antibody purification using continuous countercurrent ion-exchange chromatography. 236th ACS National Meeting & Exposition. 17-21.08.2008, Philadelphia, PA, USA.
• Müller-Späth T, Morbidelli M. 2007. Continuous Chromatography for Biomolecules, Merck European Workshop Bioprocessing, 27.06.2007, Basel, Switzerland
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2007. Purification of Monoclonal Antibodies from Cell Culture Supernatant using MCSGP, Fundamentals of Adsorption FOA9, 20.-25.05.2007, Giardini Naxos, Italy
• Müller-Späth T, Aumann L, Ströhlein G, Tarafder A, Morbidelli M. 2006.
  Purification of Biomolecules by Multicolumn Countercurrent Solvent Gradient Chromatography (MCSGP), AIChE Annual Meeting, 13.11-17.11.2006, San Francisco, CA, USA.

Posters

• Müller-Späth T, Aumann L, Ströhlein G, Kornmann H, Valax P, Delegrange L, Baer G, Lamproye A, Jöhnck M, Schulte M, Morbidelli M. 2008. Purification of monoclonal antibodies using continuous non-affinity chromatography (MCSGP). 7th European Symposium on Biochemical Engineering Science. 07.-10.09.2008, Faro, Portugal
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2008. MAb-purification by continuous countercurrent chromatography (MCSGP). European BioProcess International 2008. BioProcess 21.-24.04.2008, Vienna, Austria
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2007. MCSGP for mAb purification from clarified cell culture supernatant (cCCS), BioProduction 2007, 30. -31.10.2007, Germany, Berlin
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2006.Transition behaviour of a chromatographic countercurrent solvent gradient purification process (CSGP), International Symposium on Preparative and Industrial Chromatography and Allied Techniques, SPICA 2006, 15.10-18.10.2006, Innsbruck, Austria.
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2006. Introduction of a CIP-step into a 3-column Countercurrent Solvent Gradient Purification Process (MCSGP), BioProcess International European Conference and Exhibition 2006, 23-26.10.06, Dublin, Ireland
• Müller-Späth T, Aumann L, Ströhlein G, Morbidelli M. 2006. Operation of a 3-column countercurrent solvent gradient purification process, 19th Intern. Symposium on Preparative / Process Chromatography Ion Exchange, Adsorption / Desorption Processes & Related Separation Techniques (PREP), 14 – 17.05.06, Baltimore, USA